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A Journal on Diseases of the Respiratory System
Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Minerva Pneumologica 2009 December;48(4):389-94
Occult lung cancer detected at CT screening 15 years after craniotomy for a single brain metastasis
Scanagatta P., Veronesi G., Pelosi G., Funicelli L., Borri A., Galetta D., Gasparri R., Petrella F., Bertolaccini L., Solli P., Spaggiari L.
1 Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
2 Division of Pathology, European Institute of Oncology, Milan, Italy
3 Division of Radiology, European Institute of Oncology, Milan, Italy
4 University of Milan, School of Medicine, Milan, Italy
5 Division of Thoracic Surgery, S. Croce and Carle Hospital, Cuneo, Italy
This article reports the case of a 58-year-old man affected by multifocal adenocarcinoma of the right upper pulmonary lobe, which was diagnosed 15 years after surgical resection of a brain metastasis of adenocarcinoma. Following a low dose computed tomography scan for screening of lung cancer and a positive total-body positron-emission tomography, two nodules were detected in the right upper lobe, with no extrathoracic localization of disease or brain local recurrence. The patient under-went a right upper lobectomy and the pathologic examination of the lung tumor showed a multifocal adenocarcinoma (stage pT4pN0). The brain metastasis excised 15 years before demonstrated the same features as lung adenocarcinoma along with consistent immunoreactivity for thyroid transcription factor-1, a lung tissue-associated marker.