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MINERVA PNEUMOLOGICA

A Journal on Diseases of the Respiratory System


Official Journal of the Italian Society of Thoracic Endoscopy
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CASE REPORTS  ADVANCES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)


Minerva Pneumologica 2009 March;48(1):95-7

language: English

Allergic bronchopulmonary aspergillosis in an HIV-infected man: a long lasting manifestation of immune reconstitution?

Marruchella A. 1, Narciso P. 2

1 Respiratory Endoscopy Unit National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy
2 4th Department of Infectious Diseases National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy


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Allergic bronchopulmonary aspergillosis (ABPA) is an asthmatic syndrome in which Th2 CD4+ T cells play a major role. On the other hand CD4+ T cells are the main target of human immunodeficiency virus (HIV). The authors report a case of ABPA occurring in an HIV-infected man in the years following highly active antiretroviral therapy (HAART). They discuss the possible pathogenetic links between the immune reconstitution and the overt clinical manifestations of ABPA.

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