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Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-1723
Caples S. M.
Division of Pulmonary and Critical Care Medicine Department of Medicine Mayo Clinic, Rochester, MN, USA
Heart failure (HF) is an increasingly common public health problem that is strongly linked to both central and obstructive sleep apnea. Much attention has been given to the potential deleterious effects of obstructive sleep apnea (OSA) on the failing heart and potential mechanisms by which treatment of sleep disordered breathing may result in improved cardiac performance and long-term outcomes. There is also evidence that cardiac dysfunction may contribute to sleep disordered breathing, particularly in the case of central sleep apnea and Cheyne-Stokes respiration but also in relation to OSA. Given the prevalence and public health burden of both sleep disordered breathing and HF, the implications for effective treatment of these often comorbid conditions are enormous. This review will examine experimental and observational data which explore possible pathophysiologic mechanisms and potential targets for therapy in HF and obstructive sleep apnea.