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Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-1723
Padeletti M. 1, Jelic S. 2
1 Division of Cardiovascular Diseases University of Siena, Siena, Italy
2 Columbia University College of Physicians and Surgeons, New York, NY, USA
Obstructive sleep apnea (OSA) is a highly prevalent disorder, with significant economic impact, and is associated with excess cardiovascular morbidity and mortality. OSA is characterized by transient episodes of cessation of breathing followed by arousals from sleep. Repetitive hypoxia/reoxygenation and sleep fragmentation associated with OSA promote endothelial activation and inflammation. Endothelial activation and inflammation are important mediators of accelerated atherogenesis and consequent increased cardiovascular morbidity in OSA. The present review focuses on possible mechanisms that underlie endothelial activation and inflammation in OSA.