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Minerva Pneumologica 2008 June;47(2):73-91

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

Lung transplantation and cystic fibrosis

Spencer H., Aurora P.

1 Cardiothoracic Transplant and Respiratory Units Great Ormond Street Hospital for Children London, UK 2 Portex Respiratory Unit Institute of Child Health, UCL, London, UK


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Lung transplantation remains the only therapeutic option for children and adults with end stage cystic fibrosis (CF) lung disease who are failing maximal medical therapy. Currently, approximately 2 000 lung transplants are carried out annually worldwide and of those 600 are performed for cystic fibrosis. This review will describe the indication for referral and criteria for acceptance onto the lung transplant list and the pre-, peri- and postoperative management of CF patients undergoing transplantation. There will also be a discussion of the long-term outcomes and current controversies surrounding the potential survival benefits of lung transplantation for children with cystic fibrosis.

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