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A Journal on Diseases of the Respiratory System
Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Minerva Pneumologica 2007 December;46(4):261-74
Current therapies of advanced non-small-cell lung cancer
Heigener D. F., Reck M.
Department of Thoracic Oncology Grosshansdorf Hospital Grosshansdorf, Germany
In this review an overview of standard chemotherapies in chemonaive and pretreated non-small-cell lung cancer (NSCLC) patients is given. New approaches like platinum free regimen are discussed as well as difficult therapeutical situations like chemotherapy in elderly or patients with reduced performance status. Results of targeted therapies like epidermal growth factor receptor (EGFR), tyrosinkinase inhibitors (TKI) and EGFR monoclonal antibodies in NSCLC are described and difficulties like the problem of predictive clinical and molecular markers are considered. Innovative treatment strategies like antiangiogenic therapy with the antivascular endothelial growth factor antibody bevacizumab and its impact on daily practice is described and an outlook on new drugs like the multikinase TKI is given.