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A Journal on Diseases of the Respiratory System
Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Minerva Pneumologica 2005 December;44(4):179-96
Gene therapy of lung cancer. Experimental approaches and clinical relevance
Kuhn H., Hammerschmidt S., Wirtz H.
Lung cancer accounts for a considerable part of cancer mortality worldwide. The poor prognosis of patients with advanced stage lung cancer in response to conventional therapies, i.e. chemotherapy and radiotherapy, demands novel therapeutic approaches. Gene therapy constitutes a novel strategy. A better understanding of mechanisms involved in lung cancer pathogenesis and improved molecular biology techniques led to a growing number of approaches involving gene therapy. These approaches include replacement of tumor suppressor genes, introducing of suicide genes, inhibition of anti-apoptotic pathways, inactivation of oncogenes, inhibition of tumor angiogenesis and invasion, and the improvement of anticancer immune response. The clinical implementation of these approaches is limited by problems including gene transfer efficiency, non-specific toxicity and host immune response. This article presents an update on experimental results and their clinical application and limitation within the field of lung cancer gene therapy.