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A Journal on Diseases of the Respiratory System
Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Minerva Pneumologica 2005 September;44(3):93-102
Skeletal muscle impairment in chronic obstructive pulmonary disease
Montes de Oca M., Torres Hecker S., Celli B. R.
Chronic obstructive pulmonary disease (COPD) is primarily a lung disease. However, it has important systemic manifestations that include systemic muscle dysfunction. The mechanisms by which muscle dysfunction occurs in COPD remains a matter of debate but includes; disuse atrophy, local response to a systemic inflammatory state, local inflammation, poor energy delivery and use and accelerated damage with poor repair. This monograph reviews our current knowledge of peripheral muscle dysfunction and its mechanisms. It contains a specific review of structure and function and it expands on the relationship of peripheral muscle dysfunction and training as a way to reverse the problem. This field is bound to become a fertile ground for research. Novel therapeutic interventions may offer patients with COPD the opportunity to improve in domains different from airflow limitation, with all gains that may stem from this improvement.