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A Journal on Diseases of the Respiratory System
Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Minerva Pneumologica 2004 September;43(3):131-42
Prognostic factors in advanced stage non-small cell lung cancer
Buccheri G., Ferrigno D., Barisione E., Noceti P.
Prognostic factors continue to play a critical role in explaining the survival of lung cancer patients and prove highly important in many clinical tasks including individual counselling, the choice of treatment options, the stratification of patients by comparable risk groups and understanding the biological nature of the disease. Traditionally, the anatomic extent of the disease, the patient's performance status, and just a few other anthropometric variables are considered indispensable for a reliable prognostic assessment. Particularly in small cell lung cancer, but also in the advanced stages of non-small cell cancer, the use of simple biochemical tests is considered a valuable supplementary option. For years, for example, serum tumour markers have been used to monitor the clinical course of patients with lung cancer and their prognostic capacity is at this stage absolutely certain. More recently, some prognostic determinants of a biological nature have attracted the attention of researchers by offering new fields of research and clinical application.