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Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus
CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Bowler R. P., Balkisson R. C., Crapo J. D.
Tobacco smoke contains a high concentration of oxidants and is the primary cause of chronic obstructive pulmonary disease (COPD). Tobacco smoke also induces an inflammatory response that increases the production of a wide variety of reactive oxygen and nitrogen species (ROS/RNS) that amplify lung injury. The excessive load of both exogenous and endogenous oxidants is balanced against a variety of antioxidant defenses that are highly expressed in the lung including glutathione and extracellular superoxide dismutase. While current pharmacologic approaches to the treatment of COPD do not commonly include antioxidants, preclinical studies involving animal models suggest that antioxidant superoxide dismutase (SOD) mimetics offer a potential new therapeutic approach to the prevention and treatment of COPD.