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Minerva Pneumologica 2002 June;41(2):49-56

language: English

Exhaled nitric oxide in chronic obstructive pulmonary disease

Clini E., Ambrosino N.


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Non-invasive methods are available to assess the intensity of inflammation and oxidative stress, processes which may play a key role in the onset, progression and monitoring of chronic obstructive pulmonary disease (COPD). In this review we provide an overview of exhaled nitric oxide (eNO) which has been studied so far in patients with COPD. The main goal is to discuss eNO lung source and pathway, physiopathological significance and current role in the diagnosis, evaluation and prognosis of COPD. Data from cross-sectional, cohort and intervention studies are included, giving information on reference values in healthy persons and in COPD patients, comparisons with other inflammatory parameters and lung function in respiratory diseases, and finally on the effect of therapy.

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