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A Journal on Diseases of the Respiratory System

Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Minerva Pneumologica 2000 September-December;39(3-4):137-41

language: Italian

High values of CPK and CPK MB in 5 cases of bronchopneumonia. An example of minor rhabdomyolysis

Bartucci G., Lovreglio V.


The presence of 5 male patients (14.3%) aged between 23 and 82 years old was noted in a population of 35 cases of bronchopneumonia with transient high levels of CPK, CPK MB, LDH, aHBDH, GOT and GPT enzymes. This is attributed to minor rhabdomyolysis, namely with a solely enzymatic expression and therefore with no evidence of myoglobinemia and myoglobinuria. CPK proved to be enhanced in all 5 patients, reaching a peak between day 1 and day 3, and returning to normal levels in 4 out of 5 patients between day 4 and day 8; normal levels were not observed in one patient who died from septic shock. The isoenzyme CPK MB was enhanced in 4 of the 5 patients, whereas one patient showed normal levels both in absolute terms and as a percentage of total CPK. The highest level of CPK MB occurred on day 1 in all 4 patients, and returned to normal levels between day 2 and day 5 in 3 out of 4 patients (normalisation did not occur in the deceased patient). The authors underline that only 2 out of the 5 patients brought to their attention showed CPK levels in excess of five times the upper normal limit, and that in 3 out of 4 patients, and in one patient in particular, the level of CPK MB was strongly indicative of myocardial damage, reaching 31% of total CPK in this instance.

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