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Minerva Pneumologica 2000 March;39(1):19-32

language: Italian

Extraesophageal-manifestations of gastroesophageal reflux disease: focus on respiratory pathologies

Pellicano R.


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Gastroesophageal reflux disease (GERD) occurs with high prevalence in general population. Moreover GERD is particularly prevalent in patients with respiratory diseases. The majority of studies have focused on asthma and a causal relationship has been postulated by many investigators. However, despite the improvements in asthma outcome after anti-secretory therapy, the pathogenetic mechanism, a vagal mediated reflex or microaspiration, is unclear. Further research is needed to clarify what role GERD has on asthma pathogenesis, or viceversa, and whether a medical or surgical anti-secretory treatment is a possible approach to asthma non-responders to the conventional therapy.

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