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Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus
Online ISSN 1827-1723
Gastroesophageal reflux disease (GERD) occurs with high prevalence in general population. Moreover GERD is particularly prevalent in patients with respiratory diseases. The majority of studies have focused on asthma and a causal relationship has been postulated by many investigators. However, despite the improvements in asthma outcome after anti-secretory therapy, the pathogenetic mechanism, a vagal mediated reflex or microaspiration, is unclear. Further research is needed to clarify what role GERD has on asthma pathogenesis, or viceversa, and whether a medical or surgical anti-secretory treatment is a possible approach to asthma non-responders to the conventional therapy.