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A Journal on Diseases of the Respiratory System
Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Minerva Pneumologica 2000 March;39(1):19-32
Extraesophageal-manifestations of gastroesophageal reflux disease: focus on respiratory pathologies
Gastroesophageal reflux disease (GERD) occurs with high prevalence in general population. Moreover GERD is particularly prevalent in patients with respiratory diseases. The majority of studies have focused on asthma and a causal relationship has been postulated by many investigators. However, despite the improvements in asthma outcome after anti-secretory therapy, the pathogenetic mechanism, a vagal mediated reflex or microaspiration, is unclear. Further research is needed to clarify what role GERD has on asthma pathogenesis, or viceversa, and whether a medical or surgical anti-secretory treatment is a possible approach to asthma non-responders to the conventional therapy.