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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532
Minerva Pediatrica 2016 Nov 17
Beneficial therapeutic effects of vitamin C on recurrent respiratory tract infections in children: preliminary data
Pietro FERRARA 1, 2, Francesca IANNIELLO 1, Virginia BIANCHI 3, Fabio QUINTARELLI 2, Michela CAMMERATA 2, Enrica QUATTROCCHI 2, Gloria M. TERRANOVA 2, Giacinto A. MIGGIANO 4, Manuele CASALE 5 ✉
1 Institute of Pediatrics, Catholic University Medical School, Rome, Italy; 2 Service of Pediatrics Campus Bio-Medico University, Rome, Italy; 3 Food Sciences and Human Nutrition Unit, Campus Bio-Medico University, Rome, Italy; 4 Service of Clinical Nutrition, Catholic University of Sacred Heart, Rome, Italy; 5 Unit of Otolaryngology, Campus Bio-Medico University, Rome, Italy
BACKGROUND: To demonstrate whether supplementation of vitamin C has a beneficial effect in the prevention of recurrent respiratory tract infections (RTIs) in children. Moreover, we evaluate the main risk factors that predispose to the development of this disease.
METHODS: Sixty children have been enrolled in the study and randomized into two groups: the control group (G1 n = 33) and the group at risk of recurrent RTIs (G2 n = 27). To G2 group was administered every day 100% orange juice with the content of vitamin C 70 mg.
RESULTS: Significant reduction in the incidence rate of RTIs (episodes pre-treatment: 182-6.75 episodes/child, after-treatment: 71-2.62 episodes/child, P <0.05), were observed in G2 group.
CONCLUSIONS: The administration of vitamin C had a beneficial effect in our group of children with recurrent RTIs, reducing the number of infective episodes.