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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
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Minerva Pediatrica 2016 May 17


language: English

IgE anti-haemophilus influenzae type b (Hib) antibodies detected in serum of Hib vaccinated asthmatic and non-asthmatic pediatric patients

Tamar A. SMITH-NOROWITZ 1, Tehila A. SAADIA 1, Natalie BANNIETTIS 1, Yitzchok M. NOROWITZ 1, Rauno JOKS 2, Margaret R. HAMMERSCHLAG 1, Helen G. DURKIN 3, Stephan KOHLHOFF 1

1 Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, NY, USA; 2 Department of Medicine, Division of Allergy and Immunology, State University of New York Downstate Medical Center, Brooklyn, NY, USA; 3 Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, NY, USA


BACKGROUND: Haemophilus influenzae type b (Hib) bacterium causes severe illness in infants and children, but has largely been eliminated by introducing a universal Hib conjugate vaccine. While effects of certain vaccinations on atopic disease have been studied, little is known about the relationship between Hib vaccination and diseases of altered IgE regulation (asthma or atopy). As such, it is necessary to provide more evidence concerning Hib vaccination as a possible risk factor for atopic disease.
METHODS: Total serum IgE and IgE-and IgG-anti-Hib antibody responses were studied in Hib vaccinated asthmatic (N=14) and non-asthmatic children (N=26) (VaccZymeTM Human Anti Hib Enzyme Immunoassay Kit). Data are reported as mean optical density (OD) values.
RESULTS: We found that (1) total serum IgE levels were higher in asthmatic compared with non-asthmatic subjects (389 [±125] vs. 125 [±129], p< 0.001), and (2) IgE- and IgG- anti Hib antibody responses were similar in both asthmatic and non-asthmatic subjects (0.722 [±0.279] and 0.681 [±0.280], respectively, P=0.65; 0.450 [±0.505] and 0.573 [±0.779], respectively, P=0.580).
CONCLUSIONS: The universal Hib vaccine antigen did not result in either increased IgE- or IgG anti-Hib antibody responses in asthmatic or non-asthmatics subjects. Thus, in this cohort, no association between Hib vaccination and asthma status was identified.

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