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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532
Minerva Pediatrica 2016 Mar 18
The effect of butylphthalide on amino acid in the brain of epileptic mice
Lin HAN 1, Qingyang WANG 1, Xiaoming LIU 2 ✉
1 Department of Pharmacy, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R.China; 2 Department of Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R.China
BACKGROUND: To observe the effect of butylphthalide (NBP) on the amino acid content in the brain of epileptic mice.
METHODS: Butylphthalide (NBP) was injected intraperitoneally into the mice, and acute epileptic mice models were made after 30 min. The change of the four amino (aspartic acid, gamma-aminobutyric acid, glutamate, glycine) content in the brain of the epileptic mice was investigated.
RESULTS: The contents of Glu and Glu/GABA (model group: 38.78, NBP high dose group:5.52) in the NBP high dose group were lower compared with the model group. The difference was statistically significant.
CONCLUSIONS: Butylphthalide could regulate the balance of excitement and inhibition systems by reducing the contents of Glu and Glu/GABA, which might relieve seizures.