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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Pediatrica 2015 Nov 19
Correlation between criteria of diagnosis of low bone mineral density in adult and pediatric thalassemic patients: a prospective study
Mohseni F., Mohajeri-Tehrani M. R., Larijani B., Hamidi Z. ✉
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
AIM: Finding the correlation between criteria for low bone mineral density (BMD) in adulthood and childhood is a matter of interest. This study aimed to find how many of thalassemic patients with Z-score ≤-2 during childhood, will be found with T-score ≤-2.5 or Z-score ≤-2.0 in adulthood.
METHODS: The results of BMDs (one in childhood and one in adulthood) of 30 patients with beta thalassemia major (12 males and 18 females) with mean age of 17.63 y/o in childhood and 20.67 y/o in adulthood were studied, retrospectively. A Norland XR-46 device was used for measuring BMD.
RESULTS: “Z-score ≤-2” was found in 33% of children and “T-score ≤-2.5” and "Z-score ≤ -2.0" was found in 43 and 66% of adults, respectively. Correlation of pediatric Z-scores was good with adult T-scores and Z-scores (0.699-0.833). Relation of low BMD diagnosis in pediatric and adults was significant, and Kappa showed a moderate to good correlation between criteria for low BMD in childhood and adulthood, both with special significance in femoral region (8.10- 14.47 and 0.258-0.703, respectively). “Z-score ≤-2”, significantly increased risk of low BMD in adulthood, only when T-score ≤ -2.5 was used as low BMD criteria in adulthood (6.2-15.7). More patients dropped to poorer diagnosis group when Z-score ≤ -2.0 was used as low BMD criteria in adulthood.
CONCLUSION: There is a moderate to good agreement of these criteria, at least in femoral region but using T-score ≤ -2.5 as low BMD criteria in adulthood caused a better prediction power for Z-score ≤ -2 of childhood.