Advanced Search

Home > Journals > Minerva Pediatrica > Past Issues > Articles online first > Minerva Pediatrica 2015 Jun 23

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEMINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532

Frequency: Bi-Monthly

ISSN 0026-4946

Online ISSN 1827-1715

 

Minerva Pediatrica 2015 Jun 23

Study of multidrug resistance-associated protein 1 expression of peripheral blood of children intractable epilepsy

Yue X., Liu X., Chen S., Li R.

Department of Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, China

OBJECTIVE: The objective is to study multidrug resistance-associated protein 1 (MRP1) expression of peripheral blood of children intractable epilepsy.
METHODS: Sixty children with epilepsy admitted to outpatient and inpatient of Xuzhou Children's Hospital from November 2010 to October 2011, are divided into refractory epilepsy group and drug control group, 30 cases each Select 30 healthy children who went to hospital for health examination as control group in the same year. Use reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot to determine peripheral blood MRP1, mRNA, and protein content of 3 groups.
RESULT: MRP1 expression of refractory epilepsy group is significantly higher than that of epilepsy group with good drug control and control group, all the difference have statistical significance (P < 0.05 ): there is no significant difference of the comparison between drug well-controlled epilepsy group and the control group(P > 0.05).
CONCLUSION: MRP1 expression of peripheral blood of patients with refractory epilepsy increases.

language: English


FULL TEXT  REPRINTS

top of page