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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

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Minerva Pediatrica 2015 Jun 04

language: English

A tertiary care center’s experience with febrile seizures: evaluation of 632 cases

Elshana H.1, Özmen M. 1, Aksu Uzunhan T. 1, Uzunhan O. 2, Ünüvar E. 2, Kılıç A. 2, Tatlı B. 1, Aydınlı N. 1, Çalışkan M. 1

1 İstanbul University, İstanbul Medical Faculty, Department of Pediatric Neurology;
2 İstanbul University, İstanbul Medical Faculty, Department of General Pediatrics, Fatih-İstanbul


AIM: To evaluate demographic and prognostic features of febrile seizures in a tertiary center in Turkey.
METHODS: A retrospective study of 632 children with febrile seizure was conducted from January 1995 to January 2002 in the pediatric neurology and general pediatrics departments of İstanbul University, İstanbul Medical School. Patients data was collected and eligible patients were included in the study.
RESULTS: There were 386 male (61.1%) and 246 female (38.9%) patients, with a male-to-female ratio of 1.57. Twenty six (% 4.1) patients had prenatal, 104 (%16,5) patients had perinatal-neonatal problems. Age at first seizure was 3-72 months with an average of 20.1 months. While 193 patients (30%) were admitted with two seizures, 246 (39%) were admitted with three or more. Out of 632 patients, 501 (79.2%) had recurrences. In an average of 5.8 years (4-8.8), 30 out of 632 patients (4.7%) were diagnosed with epilepsy. First degree relative with febrile seizure, age at first febrile seizure less than 18 months, height of peak temperature (< 38.5 °C), less than 1 or 3 hours between onset of fever and seizure, complex first seizure, complex febrile seizure were all related to febrile seizure recurrence in a statistically significant way. Some risk factors for subsequent epilepsy development included complex febrile seizures and less than 1 hour of fever before febrile seizure. No patient with febrile seizure had died.
CONCLUSIONS: Complex febrile seizures and less than 1 hour of fever before febrile seizure are common risk factors for both epilepsy and febrile seizure recurrence.

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