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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

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Minerva Pediatrica 2015 Apr 15

language: English

Aminotransferase elevations in rotavirus positive and negative acute gastroenteritis and its relation with disease severity

Işık I. A. 1, Tokgöz Y. 2, Erdur B. C. 3, Arslan N. 4

1 Kayseri Education and Research Hospital, Kayseri;
2 Diyarbakır Children’s Hospital, Diyarbakır;
3 Dr. Behcet Uz Children’s Hospital, İzmir;
4 Dokuz Eylul University, Faculty of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Izmir, Turkey


AIM: The aim of this study was to investigate the frequency of elevated alanine (ALT) and aspartate aminotransferase (AST) levels in children with rotavirus positive and negative gastroenteritis as well as the average time to normalization of liver enzymes.
METHODS: 298 patients with rotavirus positive and 321 patients with rotavirus negative gastroenteritis were enrolled into the study.
RESULTS: Mean AST (56.9 ± 2.1 and 40.2 ± 0.9 U/L, respectively, p= 0.000) and ALT (33.1 ± 1.7 and 22.4 ± 0.8 U/L, respectively, p= 0.000) levels were significantly higher in the rotavirus positive than rotavirus negative patients. Logistic regression analysis showed that rotavirus positivity was significant independent factor for both AST and ALT elevation. Severity of gastroenteritis was another significant independent factor for ALT elevation. The average transaminase normalization time for AST and ALT levels were similar both rotavirus positive and negative groups.
CONCLUSION: Rotavirus positivity and severity of gastroenteritis were independent risk factors for elevated ALT levels in children with gastroenteritis.

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