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MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry


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Minerva Pediatrica 2015 Feb 25

language: English

Epidemiological factors involved in the development of bronchopulmonary dysplasia in very low birth-weight preterm infants

Lardón-­Fernández M., Uberos J., Molina-­Oya M., Narbona-­López E.

Servicio de Pediatría. Hospital Clínico San Cecilio, Granada, Spain


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BACKGROUND: In spite of the advances made in perinatal medicine, the incidence of bronchopulmonary dysplasia (BPD) has not decreased and the aetiopathogenesis of the ‘new’ BPD is still a matter for debate.
OBJECTIVES: The objectives of the present study were to a nalyse the epidemiological factors and morbidity associated with the development of BPD in a cohort of very low birth-­weight (VLBW) preterm infants.
METHOD: Retrospective observational study which included all the preterm infants with birth weight ≤ 1500g who were admitted to a tertiary-­level hospital NICU from 2008 to 2011. A neurological follow-­up was also carried out during the first two years of life. Results: A total of 140 VLBW infants were analysed. 28.4% presented oxygen dependence at 28 days, and 17.2% at 36 weeks adjusted gestational age. Predictive factors for the development of BPD were gestational age, birth weight, number of days of parenteral nutrition, number of days to achieve full enteral feeding, number of transfusions, duration of respiratory support and insulin administration, vasoactive drugs, diuretics, s edoanalgesia and postnatal corticosteroids. The neonatal morbidity associated with the development of BPD was late neonatal sepsis, patent ductus arteriosus, retinopathy of prematurity (ROP) and intraventricular haemorrhage. No significant associations with neurodevelopment impairment were observed.
CONCLUSIONS: Predictive factors for the development of BPD were respiratory support, feeding and different types of medication. Moreover, patients with BPD had a higher associated morbidity than those who did not develop BPD.

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