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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Pediatrica 2016 June;68(3):173-6

language: English

Common finding of mild hyponatremia in children evaluated at the Emergency Department and its correlation with plasma C-reactive protein values


Department of Pediatrics, Melegnano Hospital, Milan, Italy


BACKGROUND: In the context of infectious diseases, mild hyponatremia is supposed to be originated by a transient secretion of vasopressin mediated by non-osmotic stimuli. This study provides data supporting the view that mild hyponatremia during acute illnesses is related to a systemic inflammatory condition.
METHODS: A total of 328 consecutive children (aged 3 months to 17 years) underwent blood testing at the Pediatric Emergency Department over a 2-month period and were retrospectively analyzed.
RESULTS: Hyponatremia was found in 98 patients, and in most of them it was a mild condition. A significant trend towards lower levels of plasmatic sodium, along with the increase of C-reactive protein, was observed.
CONCLUSIONS: A significant relationship between plasmatic sodium levels and C-reactive protein was found, apart from of the underlying disease.

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