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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532

Frequency: Bi-Monthly

ISSN 0026-4946

Online ISSN 1827-1715


Minerva Pediatrica 2015 October;67(5):383-90


Acute pathophysiological responses in the normal lungs of newborn piglets exposed to pure oxygen

Wang P. 1, 2, Jeng M. 2, 3, 4, Fang L. 1, Soong W. 2, 3, 4

1 Department of Pediatrics, Taipei City Hospital, Women and Children’s Campus, Taipei, Taiwan;
2 Department of Pediatrics, School of Medicine, National Yang‑Ming University, Taipei, Taiwan;
3 Institute of Emergency and Critical Care Medicine, Taipei, Taiwan;
4 Department of Pediatrics, Children’s Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan

AIM: We investigated the effect of short-term pure oxygen treatment on pulmonary function, serum cytokine levels, and apoptosis in the lungs of healthy newborn piglets.
METHODS: Twelve newborn piglets were randomly assigned to receive pure oxygen (OXY) (N.=6) or room air (AIR: 21% oxygen) (N.=6) for 4 hours. Cardiopulmonary function serum levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) α were evaluated. Histology was used to assess apoptosis and morphological differences between treatment groups.
RESULTS: Four-hour treatment with 100% oxygen resulted in higher PaO2, AaDO2, and compliance of the respiratory system (Crs) in the OXY than in the AIR animals. Serum levels of IL-6 were significantly higher in OXY piglets compared with AIR piglets (P=0.009), but there were no differences between groups in the serum levels of IL-1ß and TNF-α (P=0.640 and P=0.306, respectively). The piglets in the OXY group had a greater average number of apoptotic cells in the lung than AIR piglets, although this did not reach statistical significance.
CONCLUSION: Our findings indicate that treatment with 100% oxygen for 4 hours may have clinical benefit by improving pulmonary function in normal neonates with limited increases in the inflammation and apoptosis.

language: English


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