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CURRENT ISSUEMINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532

Frequency: Bi-Monthly

ISSN 0026-4946

Online ISSN 1827-1715

 

Minerva Pediatrica 2013 June;65(3):271-8

    ORIGINAL ARTICLES

Congenital diaphragmatic hernia: experience of 14 years

Rocha G. 1, Baptista M. J. 2, Correia-Pinto J. 3, Guimarães H. 1

1 Division of Neonatology, Department of Pediatrics, Faculty of Medicine of Porto University, Hospital de São João, Porto, Portugal;
2 Division of Pediatric Cardiology, Department of Pediatrics, School of Health Sciences of Minho University, Hospital de São João, Porto, Portugal;
3 Division of Pediatric Surgery, Department of Pediatrics, Hospital de São João, Porto, Portugal

Aim: Over the last two decades, new therapies have emerged for the management of congenital diaphragmatic hernia (CDH). The aim of this paper was to review our experience in the management of newborns diagnosed with CDH over a 14-year period.
Methods: Review of maternal and infant medical records, 1997-2010.
Results: Eighty newborns with CDH; 21 (26%) were preterm and 28 (35%) of low birthweight (<2500 g), including 3 (4%) of very low birthweight (< 1500 g). Prenatal diagnosis was made in 53 (66%) cases. The location of the hernia was: left side 48 (90.5%); right 4 (7.5%); bilateral 1 (1%). Corrective surgery was performed in 58 (73%) patients. High frequency oscillatory ventilation was used in 10 (12.5%), inhaled nitric oxide in 18 (22.5%), sildenafil in 15 (18.7%) and extracorporeal membrane oxygenation in 1 (1%). The overall survival was 49% (N.=39). Since 2003, the overall survival raised to 64%. The survival rate of the appropriate for gestational age term newborns without other congenital/chromosomal anomaly or hydrops fetalis was 67% (24/36).
Conclusion: Our survival rate for congenital diaphragmatic hernia has improved over the last 14 years, associated to the use of new therapies, such as high-frequency oscillation ventilation (HFOV), inhaled nitric oxide and sildenafil.

language: English


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