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MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry


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Minerva Pediatrica 2010 December;62(6):599-603

language: English

Treatment of congenital ichthyosis with acitretin: a case report

Cakmak A., Baba F., Cakmak S., Shermatov K., Karazeybek H.

1 Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey
2 Department of Pathology, Harran University School of Medicine, Sanliurfa, Turkey
3 Department of Ophtalmology, Dicle University School of Medicine, Sanliurfa, Turkey
4 Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey


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The authors assessed the clinical efficacy, tolerability and safety of acitretin in a patient with ichthyosis. A newborn infant with ichthyosis who presented at birth with collodion baby appearance, was treated with acitretin. A moderate response to acitretin therapy (1 mg/kg/day) administered for 6 months was observed, with improvement in cutaneous lesions. Clinical improvement was achieved shortly after treatment. The treatment resulted in a satisfactory improvement in the skin condition of the case. The tolerance to the drug was good. Side effects were not observed. The oral acitretin treatment is efficient in severe congenital ichthyosis.

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alpaycakmak@gmail.com