Home > Journals > Minerva Pediatrica > Past Issues > Minerva Pediatrica 2010 June;62(3) > Minerva Pediatrica 2010 June;62(3):273-84

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry


Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,764


eTOC

 

REVIEWS  GROWTH AN NUTRITION IN CHILDREN WITH CHRONIC RENAL DISEASE


Minerva Pediatrica 2010 June;62(3):273-84

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Bone cell biology and pediatric renal osteodystrophy

Haffner D., Fischer D. C.

Department of Pediatrics, University of Rostock, Rostock, Germany


PDF  


Patients with chronic kidney disease (CKD) show a broad spectrum of clinical symptoms intimately related to the disturbed mineral and bone metabolism and summarized as CKD-mineral-bone disorder (CKD-MBD). Whereas in adults an impaired bone metabolism translates mainly into an increased risk of fractures, in pediatric CKD patients rickets, skeletal deformations, and severe growth failure are additional and severe clinical findings. Further-more, an elevated Ca x P ion product, secondary hyperparathyroidism (sHPT) as well as concomitant calcitriol medication have been linked to ectopic (vascular) calcification, in which is strongly associated with the dramatically high cardiovascular morbidity and mortality even in pediatric CKD patients. Thus, in these patients the impaired mineral metabolism is the link between skeletal and cardiovascular disease. In other words, the complex interplay between kidney, skeleton, parathyroid gland, the intestine and the cardiovasculature is severely disturbed in CKD. This review summarizes the recent findings in our understanding of bone cell biology and alterations of mineral metabolism in children with CKD.

top of page

Publication History

Cite this article as

Corresponding author e-mail

dieter.haffner@med.uni-rostock.de