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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

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Minerva Pediatrica 2010 June;62(3):239-44


language: Italian

Prognosis and treatment of Vernal keratoconjunctivitis in pediatric age: pilot study on 197 patients

Spadavecchia L. 1, Fanelli P. 1, Tesse R. 1, Rizzo G. 2, Procoli U. 2, Bellizzi M. 2, Armenio L. 1

1 Dipartimento di Biomedicina Dell’Età Evolutiva, Clinica Pediatrica “S. Maggiore”, Università degli Studi di Bari, Bari, Italia 2 Dipartimento di Oftalmologia e Otorinolaringoiatria, Clinica Oculistica II, Università degli Studi di Bari, Bari, Italia


AIM: Corticosteroids and high-concentrated cyclosporine eyedrops have been used for treatment of severe vernal keratoconjunctivitis (VKC) cases. The purpose of our study was to verify the efficacy of 1% topical cyclosporine in improving severe form of VKC in childhood and investigate for factors affecting the response to therapy.
METHODS: We conducted an open trial involving 197 children with severe VKC, who received topical cyclosporine 1% for four months. Ocular subjective symptoms and objective signs were scored in all children at entry, two weeks and four months. Skin prick tests and microscope endothelial cells evaluation were also performed; serum IgE and cyclosporine levels were assessed.
RESULTS: The mean score values for severity of subjective symptoms and objective signs were significantly decreased after 2 weeks, and 4 months, compared with those at entry (P<0.001) in all children. Cyclosporine serum levels were not detectable at the end of therapy, nor were endothelial corneal cells damaged. Patients who started the therapy at the beginning of the disease and/or received long-term regimen of treatment with cyclosporine had a faster improvement of ocular signs and symptoms, compared to all other patients.
CONCLUSION: Our findings suggest that 1% cyclosporine concentration administrated topically at the beginning of the disease and for a long-term period might be the most effective treatment to control symptoms and local inflammation in severe forms of VKC in childhood.

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