Home > Journals > Minerva Pediatrica > Past Issues > Minerva Pediatrica 2007 December;59(6) > Minerva Pediatrica 2007 December;59(6):817-23

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry


Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,764


eTOC

 

CASE REPORTS  


Minerva Pediatrica 2007 December;59(6):817-23

Copyright © 2007 EDIZIONI MINERVA MEDICA

language: English

Neonatal presentation of Prader Willi sindrome. Personal records

Maggio M. C., Corsello M., Piccione M., Piro E., Giuffrè M., Liotta A.

Maternal and Child Health Department University of Palermo, Palermo,Italy


PDF  


Prader Willi Syndrome (PWS) is characterized by typical appearance, obesity, short stature, hypothalamic hypogonadism, cryptorchidism, hypotonia, behavioural abnormalities and mental retardation. It is considered as a continuous genes syndrome with different genotypes: microdeletion of the region 15q11-q13 with paternal imprinting; maternal uniparental disomy (UPD) of chromosome 15; chromosomal rearrangement. Clinical manifestations evolve with age from newborn (hypotonia, poor sucking, hypoplastic external genitalia) to childhood (delay in psychomotor development, hyperphagia, obesity, acromicria and craniofacial dysmorphisms). We present five newborns who received an early diagnosis, based on clinical presentation. The early treatment and follow-up can in fact improve the natural evolution of the syndrome in order to prevent respiratory tract diseases and obesity, and to improve growth.

top of page

Publication History

Cite this article as

Corresponding author e-mail