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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,532
Minerva Pediatrica 2007 April;59(2):97-105
Pulmonary infections in preterm newborns
Vendettuoli V., De Cunto A., Tana M., Tirone C., Boccacci S., Vento G., Romagnoli C.
Divisione di Neonatologia Istituto di Clinica Pediatrica Policlinico A. Gemelli Università Cattolica del Sacro Cuore, Roma
Aim. The aim of this study was to evaluate retrospectively the incidence and etiology of connatal pneumonia and ventilator-associated pneumonia (VAP) in preterm newborns who had birth weight £1 250 g and required intubation for at least 12 h.
Methods. We have reported data about preterm newborns who had birth weight ≤1 250 g and required intubation for at least 12 h with diagnosis of connatal pneumonia and VAP, admitted to the neonatal intensive care unit from 1994 to 2004. We divided these 11 years into 4 periods. For each period we determined etiology associated with connatal pneumonia or VAP.
Results. A total of 417 patients were studied; 311 (74.6%) required mechanical ventilation (MV) for more than 48 h (the least for the diagnosis of VAP). Connatal pneumonia occurred in 35/417 patients (8.4%). VAP incidence did not change over time showing a slight increase in the last 2 years (from 27% to 33%). Mycoplasma and Chlamydia as causative organisms of connatal pneumonia dissapear during years. Gram-negative micro-organisms were isolated more frequently in last years in VAP episodes.
Conclusion. The incidence of VAP does not decrease over time altough lenght of MV was reduced. Addional studies are needed to improve criteria for the diagnosis and prevention of VAP in NICU patients.