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A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry

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Minerva Pediatrica 2001 August;53(4):271-4

language: English

Glucose or sucrose as an analgesic for newborns: a randomised controlled blind trial

Guala A., Pastore G., Liverani M. E., Giroletti G., Gulino E., Meriggi A. L., Licardi G., Garipoli V.

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Background. To evaluate the effect of different oral glucose or sucrose solutions on the pain response to heelstick in newborns.
Methods. Design: randomised double blind placebo controlled trial of water (control) versus one of three solutions of glucose ­ namely 5, 33 and 50% ­ or one of two solutions of sucrose (33% and 50%) or nothing. Setting: postnatal ward. Patients: seven groups of 20 healthy newborns (gestational age 38-41, weighing over 2500 g) were randomised to receive 2 ml of one of the six solutions on the tongue inmediately before heelstick procedure. Main outcome measure: heart rate before, during and three minutes after the procedure.
Results. Even if the trend of the cardiac rates did not reach statistic significance, glucose solution 33 and 50% proved to be the most effective in reducing pain response.
Conclusions. Sweet solutions may be an easy, useful, safe and cheap analgesic for minor invasive procedures in newborns.

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