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MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
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Minerva Pediatrica 2001 February;53(1):1-6

language: English

Serum IgD levels in children with atopic asthma. A longitudinal study

Salpietro D. C., Masaracchio A., Turiaco A., Di Bella M. R., Toscano V., Merlino M. V.


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Background. Serum IgD and IgE levels were measured in children with atopic asthma and in control Group in order to determine their relationship with clinical status.
Methods. Samples of venous blood (of 5 cc) were drawn from 25 asthmatic children (Group A) and 25 healthy children (Group B) at the moment of first diagnosis (T0), after 6 months (T180) and after 18 months (T540). To measure IgD, an ELISA assay based on the ''sandwich'' principle was used.
Results. At T0, IgD were significantly higher in Group A (182.7 5±88.18 IU/ml) in comparison with Group B (69.58±4.93 IU/ml, p<0.0001); IgD levels decreased in Group A at T540.
Conclusions. In conclusion, a significant increase of IgD levels observed in children at first signs of asthma and the following normalization of these same levels after 18 months, may represent a non specific response or an attempt of the organism to block asthma, favouring therefore immunologic tolerance.

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