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Online ISSN 1827-1707
Ziranu A., Mariotti F., Perisano C., Stomeo D., Maccauro G.
Department of Geriatrics Sciences, Neuro‑Sciences and Orthopedics Sciences, Sacro Cuore Catholic University, Rome, Italy
Chondroblastoma is a benign bone tumor that arises from secondary centers of ossification. It is an uncommon neoplasm, accounting for approximately 1% to 3% of all primary bone tumors. There is a male predominance and the peak incidence is in the second decade of life. Chondroblastoma usually affects long bone epiphysis and its most typical locations are the distal femur, proximal humerus and proximal tibia. Clinical presentation is non-specific. Pain is the most common symptom, edema and limitation of the range of motion are the most reported signs. Bone scans, computed tomography scans, and magnetic resonance images are used for staging the tumor before surgery. Confirmation by biopsy is mandatory in case of doubtful radiographic appearance. Chondroblastoma is histologically characterized by chondroblastoma cells, osteoclast-like giant cells and sometimes reactive osteoid. Cytogenetic reports of chondroblastoma are few and suggest preferential involvement of chromosomes 2, 3, 5 and 8. Treatment for chondroblastomas of tibia and femur is usually curettage with bone graft while partial resection of the patella is the predominant treatment for tumors at this site. Prognosis depends basically on a relatively high rate of recurrence which is between 5% and 35%. Metastasis is extremely unlikely but possible, especially to the lungs. Here, we reviewed clinical, pathological and radiological features and treatment modalities of chondroblastoma, with an emphasis on lesions occurring in the knee.