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Della Guardia C. 1, Montorio D. 1, Minervino C. 1, Chiariello Vecchio E. 1, Cesarano I. 1, Cennamo G. 1, De Vito M. 1, Orefice G. 2
1 Dipartimento di Scienze Oftalmologiche, Università degli Studi di Napoli, “Federico II”, Napoli, Italia;
2 Dipartimento di Scienze Neurologiche, Università degli Studi di Napoli, “Federico II”, Napoli, Italia
aim. In vivo, multiple sclerosis (MS) eyes have reduced ganglion cell complex (GCC) thickness and macular volumes by optical coherence tomography (OCT). Using a fourier-domain OCT, this study want determine the relation of GCC and macular volumes to visual function in MS eyes with or without an history of optic neuritis (ON).
Methods. Thirty eyes of fifteen patients with MS and twelve eyes of six disease-free control participants were studied using FD-OCT (RTVue-100; Optovue Inc, Fremont, CA) to measure GCC thickness and macular volumes. Visual function was assessed using Early treatment diabetic retinopathy study chart (ETDRS).
Results. MS patient eyes had significantly lower GCC thickness than the control eyes (P<0.0001). Within the MS group, eyes with a history of ON (N.=6), had significantly lower GCC thickness than MS eyes with no ON history (P<0.001). MS patient eyes had significantly lower macular volumes than the control eyes (P=0.004). Within the MS group, eyes with a history of ON (N.=6) had significantly lower macular volumes than MS eyes with no ON history (P=0.01).
Conclusion. This pilot study has characterized alteration of the GCC and macular volumes, particularly in those with a history of acute ON. FD-OCT could substantially increase our understanding of the mechanisms of tissue injury in MS, could be used to identify new therapeutic strategies focused on neuroprotection of central axonal and neuronal structures, and could even enable the detection and monitoring of the processes of neurorestoration.