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Minerva Oftalmologica 2012 September;54(3):85-92

language: English

An internal medicine perspective of risk factors for primary open-angle glaucoma (POAG) progression: a study carried out in Turin

Actis A. G. 1, Penna R. 1, Brogliatti B. 1, Versino E. 2, Grignolo F. M. 1, Rolle T. 1

1 Department of Clinical Physiopathology, Ophthalmic Section, University of Turin, Turin, Italy;
2 Department of Clinical and Biological Studies, San Luigi Gonzaga Medical School, University of Turin, Turin, Italy


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AIM: Aim of our retrospective, observational study is to describe features of a population sample, affected by primary open angle glaucoma (POAG) under medical treatment, in order to value damage progression on the basis of the emerged individual risk factors.
METHODS:We included 190 patients (377 eyes) examined in the last year evaluating the individual features effect (possible risk factors for the progression) on the mean deviation (MD) dependent variable of the standard automated perimetry. Progression has been defined with the statistical method of the General Linear Model considering three subsequent follow-up visits (T0, T1 e T2).
RESULTS: Factors reaching statistical significance, determining a worsening of the MD variable, are: age (P<0.0001), intraocular pressure (IOP) at follow-up (P<0.0001), male gender (P<0.0001). For each mmHg of increasing in the IOP at follow-up, the average worsening of the MD variable was -6.32 dB (average follow-up 4.7 years), i.e., -1.33 dB average worsening in one year of follow up for each increase of one IOP unit (mmHg).
CONCLUSION: This study confirms that IOP remains the main risk factor for glaucoma progression. Only a careful clinical history and a global evaluation of the patient suffering from glaucoma allow us to set out a follow-up with an appropriate timing, in order to assess the correct rate of progression.

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