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A Journal on Ophthalmology




Minerva Oftalmologica 2012 June;54(2):53-8

language: Italian

Post-operative results of corneal collagen cross-linking for progressive keratoconus

Rossi S., Testa F., Santamaria C., Orrico A., Boccia R., Brunetti Pierri R., D’alterio F. M., Simonelli F., De Rosa G.

Dipartimento di Oftalmologia, Seconda Università di Napoli, Napoli, Italia


Aim. The aim of this paper was to report 24-month refractive, topographic, tomographic and aberrometric outcomes after corneal collagen cross-linking in patients with progressive advanced keratoconus.
Methods. Prospective, non randomized single-center clinical study involving 10 eyes. Main outcome measures included uncorrected and best spectacle-corrected visual acuities, sphere and cylinder refraction, topography, tomography, aberrometry, pachy­metry, intraocular pressure and endothelial cell count evaluated at baseline and follow-up at 3, 12, and 24 months after treatment.
Results. Two years after treatment, uncorrected and best spectacle-corrected visual acuities improved significantly (P=0.004 and P<0.001, respectively) and mean spherical equivalent refractive error decreased significantly (P<0.001). Mean average pupillary power, and apical keratometry decreased significantly (P<0.001). Total corneal wavefront aberrations decreased significantly. Pachymetry, intraocular pressure and endothelial cell counts did not change significantly.
Conclusions. Two years postoperatively, corneal collagen cross-linking appears to be effective in improving uncorrected and best spectacle-corrected visual acuities in eyes with progressive keratoconus by significantly reducing corneal average pupillary power, apical keratometry, and total corneal wavefront aberrations.

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