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A Journal on Ophthalmology
Minerva Oftalmologica 2010 June;52(2):87-92
Orsoni J. G., Rampini A.
UOS “Malattie Infiammatorie e Autoimmuni Oculari”, Sezione di Oftalmologia-Dipartimento OOOCF, Università di Parma, Parma, Italia
Ocular cicatricial pemphigoid is a blistering autoimmune disease long known to interest the skin, oral, respiratory and conjunctival mucosa. Without early recognition of the disease, the end stage of the ocular involvement is irreversible bilateral blindness. Nowadays, basic research focuses on the recognition of specific epitopes which are probably different in skin, mouth and eye. While medical genetic research highlights such specific problems, the clinical picture of the disease in its first stages is mainly overlooked by the treating ophthalmologist. A late diagnosis may be fatal for the patient: collaboration with a third referral centre must begin before irreversible conjunctival and corneal damage manifests. A knowledge of this disease is mandatory for every ophthalmologist.