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Minerva Oftalmologica 2008 December;50(4):107-11

language: Italian

Orbital retinoblastoma: clinical and therapeutic aspects

Hadjistilianou T., De Francesco S., Menicacci F., Galluzzi P., Acquaviva A., De Luca M., Borri M., Menicacci F., Motolese E.

Dipartimento di Scienze Oftalmologiche e Neurochirurgiche Università degli Studi di Siena Policlinico Le Scotte, Siena, Italia


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Aim. This study describes the pathogenesis of orbital retinoblastoma, its treatment and prognosis.
Methods. Medical records were reviewed of 330 cases of retinoblastoma treated between 1980 and 2006 at our institute, 6 of which were orbital retinoblastoma.
Results. Survival after diagnosis of orbital retinoblastoma was found to depend on the presence or absence of metastases to the central nervous system and/or distant metastasis.
Conclusion. Isolated orbital retinoblastoma carries a good prognosis when promptly diagnosed and treated. When associated with distant metastasis and/or involvement of the central nervous system, prognosis is poor.

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