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A Journal on Ophthalmology
Minerva Oftalmologica 2008 December;50(4):107-11
Orbital retinoblastoma: clinical and therapeutic aspects
Hadjistilianou T., De Francesco S., Menicacci F., Galluzzi P., Acquaviva A., De Luca M., Borri M., Menicacci F., Motolese E.
Dipartimento di Scienze Oftalmologiche e Neurochirurgiche Università degli Studi di Siena Policlinico Le Scotte, Siena, Italia
Aim. This study describes the pathogenesis of orbital retinoblastoma, its treatment and prognosis.
Methods. Medical records were reviewed of 330 cases of retinoblastoma treated between 1980 and 2006 at our institute, 6 of which were orbital retinoblastoma.
Results. Survival after diagnosis of orbital retinoblastoma was found to depend on the presence or absence of metastases to the central nervous system and/or distant metastasis.
Conclusion. Isolated orbital retinoblastoma carries a good prognosis when promptly diagnosed and treated. When associated with distant metastasis and/or involvement of the central nervous system, prognosis is poor.