Total amount: € 0,00
HOW TO ORDER
A Journal on Ophthalmology
Minerva Oftalmologica 2008 December;50(4):95-9
Epidemiology of retinoblastoma treatment: a large-scale case series review
Hadjistilianou T., De Luca M., De Francesco S., Borri M., Motolese I., Menicacci F.
Dipartimento di Scienze Oftalmologiche, Università degli Studi di Siena, Siena, Italia
Aim. This in-depth epidemiology study presents the main advances in the treatment of retinoblastoma.
Methods. From a medical record review of 466 patients (180 with bilateral and 286 with unilateral retinoblastoma) treated between 1952 and 2007, four reference periods were defined: first period (1952-1980); second period (1980-1990); third period (1990-2000), fourth period (2000-2007).
Results. First period: enucleation was performed in 100% of cases for unilateral retinoblastoma, in 70% for bilateral tumor (the more eye affected), and bilateral enucleation in 30% of cases; second period: in 97% cases for unilateral tumor, in 81% for bilateral tumor (the more eye affected), and bilateral enucleation in 13% of cases; third period: in 89% of cases for unilateral tumor, in 77% for bilateral tumor, and bilateral enucleation in 12% of cases; fourth period: in 79% of cases for unilateral tumor, in 68% for bilateral tumor, and bilateral enucleation in 9% of cases.
Conclusion. Epidemiological data analysis showed a gradual reduction in the use of enucleation and a progressive increase in conservative treatment for retinoblastoma.