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Hadjistilianou T., De Luca M., De Francesco S., Borri M., Motolese I., Menicacci F.
Dipartimento di Scienze Oftalmologiche, Università degli Studi di Siena, Siena, Italia
Aim. This in-depth epidemiology study presents the main advances in the treatment of retinoblastoma.
Methods. From a medical record review of 466 patients (180 with bilateral and 286 with unilateral retinoblastoma) treated between 1952 and 2007, four reference periods were defined: first period (1952-1980); second period (1980-1990); third period (1990-2000), fourth period (2000-2007).
Results. First period: enucleation was performed in 100% of cases for unilateral retinoblastoma, in 70% for bilateral tumor (the more eye affected), and bilateral enucleation in 30% of cases; second period: in 97% cases for unilateral tumor, in 81% for bilateral tumor (the more eye affected), and bilateral enucleation in 13% of cases; third period: in 89% of cases for unilateral tumor, in 77% for bilateral tumor, and bilateral enucleation in 12% of cases; fourth period: in 79% of cases for unilateral tumor, in 68% for bilateral tumor, and bilateral enucleation in 9% of cases.
Conclusion. Epidemiological data analysis showed a gradual reduction in the use of enucleation and a progressive increase in conservative treatment for retinoblastoma.