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Iovine A., Carelli R., Boccuzzi D., Fimiani F.
Dipartimento di Scienze Oftalmologiche Facoltà di Medicina e Chirurgia Università “Federico II”, Napoli
Aim. The aim of this study was using electrooculography (EOG) for an objective assessment of congenital nystagmus in patients undergoing pharmacological treatment. Methods. Seven patients affected by congenital nystagmus were studied at the Oftalmology Department of University Federico II in Naples, between 2004 and 2006. Two patients had oculo- cutaneous albinism. The patients underwent ophthalmological examination, visual acuity measurement, orthoptic examination and EOG evaluation (foveation period, position of minimum nystagmus and non-foveating peak) before and after treatment. Three out of seven patients have undergone treatment with botulinum toxin and four surgical treatment.
Results. EOG has proved useful in evaluating the effectiveness of therapy in all patients undergoing surgical and/or pharmacological treatment. A significant reduction of average frequency,amplitude, intensity and foveation time
in patients after treatment was noticed. The mean visual acuity in subjects before treatment was 2/10. After treatment the mean visual acuity was 3.3/10.
Conclusion. The EOG was performed before and after surgery and/or pharmacological treatment. Regardless of the effectiveness of treatment, the EOG was able to accurately quantify the changes in parameters related to nystagmus,
data not otherwise available only with orthoptic and ophthalmological examinations.