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A Journal on Ophthalmology
Minerva Oftalmologica 2002 September-December;44(3-4):151-4
The ''biologic'' rehabilitation in juvenile maculopathies
Nuzzi R., Donati S., Cometto A., Grignolo F. M.
The degeneration of the choriocapillary-pigmented epithelium-photoreceptors complex is the cause of the visual loss in these patients. The preventive therapy has an important role but it's not sufficient. The medical and surgical therapy doesn't give a complete recovery of the functional and anatomical structures of the eye, and neither can stop the pathology. The young age of these patients needs to develop a serious rehabilitation for a better quality of life. Different lines of researches are evaluating the progresses of tissue or cells implants on the atrophic areas of the retina. The aim of our study is to verify the ability of staminal cells to integrate and differentiate in the host tissue. The proliferation and plasticity of these cells permit to have a useful substrate for action of the different growth factors. A functional artificial system could be a different approach but it needs a correct surgical and medical method. For a correct transmission it needs the creation of synaptic connections and the complete tolerance from the host tissue.