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A Journal on Ophthalmology
Minerva Oftalmologica 2000 September-December;42(3-4):29-32
Prevention of intraocular pressure increase in Nd-YAG capsulotomy using Apraclonidine hydrochloride 0.5%
Morreale Bubella D., Vadalà M.
The increase of intraocular pressure (IOP) is undoubtedly one of the most frequent consequence of laser procedure on the anterior segment. Several hypotensive agents have been tested in reducing ocular hypertension after posterior capsulotomy, none of them demonstrated preventive effect. In this randomised group-control study we verified Apraclonidine hydrochloride 0.5% solution preventive efficacy in 16 patients in comparison with 17 patients treated with placebo, In the control group, the mean basal IOP was 14±4 mmHg, and it increased to 16±5 mmHg (+14.6%) ten minutes post-laser, and to 18±4 mmHg (+27.8%) after 150'. In the group treated with Apraclonidine hydrochloride 0.5%, mean basal IOP was 15±3 mmHg, increasing to 17±4 mmHg (+13.7%) ten minutes after capsulotomy, and decreased to 13±5 mmHg after 150'. No sign of anterior inflammation was observed all over the follow-up.