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A Journal on Ophthalmology
Minerva Oftalmologica 1999 March;41(1):25-34
Preventing postoperative vomiting in eyesurgery. A comparison between ondansetron and metoclopramide
Menzano A., Garino A., Leporati G., Mordillo P., Bortuzzo A. M., Rizza V., Bellomo C.
Aim. The study compares two antihemetic drugs: metoclopramide and ondansetron in the prevention of PONV in eyesurgery. Experimental design: a random and double blind study was performed in patients undergoing vitrectomy and detached retina surgery. Setting: operating theatre and hospital ward. Patients: a group of 132 patients with detached retina or hemovitreus received antihemetic prophylaxis. Parameters evaluated: the following were examined: a) predisposing factors (age, sex, pre-existent pathologies); b) the onset of nausea and vomiting at 6, 12, 24, 48 hours after the operation; c) any postoperative surgical complications caused by vomiting.
Results. Patients treated with ondansetron had a low incidence of nausea and vomiting and did not require additional doses of the drug in the following hours, contrary to the metoclopramide treated group.
Conclusions. The results confirm the superio-rity of ondansetron compared to metoclopramide in the control of postoperative vomiting.