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A Journal on Forensic Medicine




Minerva Medicolegale 2014 December;134(4):217-27

language: Italian

Obsessive-compulsive disorder (ocd): from clinical to medico-legal implications in the assessment of disability

Mandarelli G. 1, Pasquini M. 2, Bonanni E. 3, Berardelli I. 2, Ferracuti S. 1

1 Dipartimento di Neuroscienze, Salute Mentale e Organi di Senso (NESMOS), Facoltà di Medicina e Psicologia, Università di Roma “Sapienza”, Ospedale Sant’Andrea, Roma, Italia;
2 Dipartimento di Neurologia e Psichiatria, Facoltà di Medicina e Odontoiatria, Università di Roma “Sapienza”, Roma, Italia;
3 Dipartimento di Scienze Anatomiche, Istologiche, Medico‑Legali e dell’Apparato Locomotore, Facoltà di Farmacia e Medicina, Università di Roma “Sapienza”, Roma, Italia


Obsessive-compulsive disorder (OCD) is among the leading causes of disability in adults. Despite growing evidence provided by genetic, clinical and neuroimaging studies, the pathophysiology of this disorder is still a matter of debate. Further complexity comes from the great variability in individual response to psychiatric treatment as well as pharmacoresistance. Moreover, the variable burden of OCD is associated with the heterogeneous psychopathological symptoms and course characteristic of the disease. In the present study, we will first discuss the clinical features of OCD, then we will focus on the most reliable assessment procedures that can be used to evaluate patients’ disability within a medico-legal context.

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