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Minerva Medicolegale 2010 July-December;130(3-4):139-44

language: English

Population study of X-STRs in an Italian population sample

Fabbri M., Gaudio R. M., Tarantino S., Venturi M., Tassi F., Avato F. M.

Section of Legal and Insurance Medicine, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy


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Aim and methods. The aim of this work was to evaluate eight X-STRs loci localized along the X Chromosome in four different linkage groups rapresented by DXS8378, HPRTB, DXS7423, DXS7132, DXS10134, DXS10074, DXS10101, DXS10135, in an Italian population sample (Ferrara) consisting in 130 unrelated individuals (70 male and 60 female). This markers reveal their utility in paternity deficiency cases and in kinship parentage testing when only remote relatives are available for the analysis.
Results. As already demonstrated by other authors, X-STRs become a powerful tool in paternity testing and in complex kindship cases, in particular when a biological sample of the putative father is not avaiable for the laboratory analysis. Another situation where these markers are very useful is rapresented by maternity testing and the analysis of female/male stains. In these forensic caseworks, X-STRs may be a useful complement to analysis of autosomal markers in identifying female DNA.
Conclusion. Further studies are needed on allele frequencies to evaluate the extent of polymorphism in different populations and to establish reference databases useful for forensic applications and for anthropological studies. Forensic parameters revealed, with the exception of DXS8378 and DXS7423, values broadly in line with those expected from the markers used in the field of human identification, especially for DXS10135. All loci investigated were found to be in HWE in the female subsample (60 samples). These results confirmed the robustness of X-STRs for forensic purposes as a set of additional markers may be helpfull to the examiner as previously described by other authors.

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