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A Journal on Internal Medicine

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Minerva Medica 2016 Oct 20

language: English

The effect of prediabetes on hepatocellular carcinoma risk: a systematic review and meta-analysis

Wei G. XU, Yun F. QIAN, Jun WU

Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, China


BACKGROUND: Some studies suggested an increased risk of hepatocellular carcinoma (HCC) risk in subjects with prediabetes, whereas other studies have reported negative results. Therefore, we did this meta-analysis to assess the role of prediabetes on HCC risk.
METHODS: We searched studies from PubMed, Embase, and Web of Science databases. The strength of association between prediabetes and HCC risk was assessed by calculating hazard ratio (HR) with 95% CI.
RESULTS: A total of 8 cohort studies and 1 case-control study with 1384594 individuals were included. Patients with prediabetes showed an increased HCC risk (HR = 1.21; 95%CI, 1.13–1.30; P < 0.00001). Subgroup analyses were performed according to race and gender. The results showed that both Asians with prediabetes (HR = 1.19; 95%CI, 1.11–1.28; P < 0.00001) and Caucasians with prediabetes (HR = 2.12; 95%CI, 1.36–3.31; P = 0.001 were significantly associated with increased risk of HCC, respectively. In the subgroup analysis by gender, both male patients with prediabetes (HR = 1.49; 95%CI, 1.03–2.15; P = 0.03) and female patients with prediabetes (HR = 1.24; 95%CI, 1.01–1.52; P = 0.04) showed increased risk of HCC, respectively.
CONCLUSIONS: In conclusion, this meta-analysis demonstrated that prediabetes might be a risk factor of HCC.

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