Total amount: € 0,00
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236
Jiu Y. LIU 1, Xiao J. YANG 1, Xia F. GENG 1, Chao Q. HUANG 1, Yang YU 1, Yan LI 1, 2
1 Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China; 2 Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital Affiliated to the Capital Medical University, Beijing, China
INTRODUCTIONː Tumor-associated macrophages (TAM) play a dual role in the development of gastric cancer (GC). This study aims to analyze the prognostic value of TAM density in GC patients.
EVIDENCE ACQUISITIONː We conducted a meta-analysis of 11 studies (N.=1043) to investigate the correlation between TAM density and the overall survival (OS) or disease free survival (DFS) of GC patients. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by the STATA statistical software.
EVIDENCE SYNTHESISː The HR of OS of GC patients with high-density TAM is 1.56 (95% CI: 0.90~2.22, P<0.001) as compared with those with low-density TAM, and that of DFS is 1.10 (95% CI: 0.16~2.03, P=0.022), indicating that TAM density does not significantly predict the poor survival of GC. A subgroup analysis by ethnicity also revealed no significance effect between TAM density and a worse OS among both Asians and Caucasians (Asians: HR=1.47, 95% CI: 0.76~2.18, P<0.001; Caucasians: HR=2.23, 95% CI: 0.62~3.84, P=0.007, respectively).
CONCLUSIONSː Our findings provide empirical evidence that TAM density is not an independent predictor for the survival of GC patients.