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A Journal on Internal Medicine
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236
Minerva Medica 2016 October;107(5):294-9
Obstructive sleep apnea syndrome is a risk factor of hypertension
Fanbo MENG 1, Jianghong MA 2, Wei WANG 2, Baisong LIN 2 ✉
1 Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China; 2 Department of Cardiac Surgery, China-Japan Union Hospital of Jilin University, Changchun, China
INTRODUCTION: Some studies investigated the association between obstructive sleep apnea syndrome (OSAS) and hypertension risk. However, the results remained inconclusive. Thus, we performed a meta-analysis to clarify the association of OSAS and hypertension risk.
EVIDENCE ACQUISITION: Online electronic databases (PubMed and EMBASE) was searched. The strength of association between the OSAS and hypertension risk was assessed by calculating OR with 95% CI.
EVIDENCE SYNTHESIS: A total of 6 articles with 20,637 patients on OSAS and hypertension risk met the study inclusion criteria, and were included in the meta-analysis. OSAS was associated with a significantly increased risk of hypertension (OR=1.41; 95%CI, 1.29–1.8855 I2=20%). In the race subgroup analysis, Caucasians with OSAS had increased hypertension risk (OR=1.43; 95%CI, 1.29-1.59; I2=20%). In the subgroup analysis according to gender, male OSAS patients were significantly associated with risk of hypertension (OR=1.59; 95%CI, 1.16-2.17; I2=0%), while female OSAS patients were not significantly associated with risk of hypertension (OR=1.18; 95%CI, 0.80-1.73; I2=0%). All of the different severities of OSAS patients had an increased hypertension risk (mild: OR=1.26; 95%CI, 1.17-1.35; I2=45%; moderate: OR=1.50; 95%CI, 1.27–1.76; I2=46%; severe: OR=1.47; 95%CI, 1.33-1.64; I2=63%).
CONCLUSIONS: In conclusion, this meta-analysis suggested that OSAS may be associated with hypertension risk.