Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2016 August;107(4) > Minerva Medica 2016 August;107(4):239-44

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA MEDICA

A Journal on Internal Medicine


Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,878


eTOC

 

REVIEWS  


Minerva Medica 2016 August;107(4):239-44

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Estrogen and thyroid diseases: an update

Yihan LU 1, Jian LI 2, Jing LI 1

1 Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital, China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang, China; 2 Department of Surgery, Jinqiu Hospital of Liaoning, Shenyang, China


PDF  


Most of thyroid diseases show female predilection, especially autoimmune thyroid diseases (AITD) and thyroid cancer (TC). We give an updated brief review here, focusing on estrogen, estrogen receptor (ER) and AITD as well as TC. Estrogen can regulate the functions of nearly all immunocyte subsets, which may contribute to the development of AITD. However, there was still lack of direct studies on ER subtype-specific effects on AITD. Recently, the local expression of ER subtypes and their individual mediated actions in the pathogenesis of TC have already received much attention. ERα activation seems to exacerbate the development of TC, while wild-type ERβ (ERβ1) plays a protective role against TC.

top of page

Publication History

Cite this article as

Corresponding author e-mail

lijingendocrine@126.com.