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Minerva Medica 2016 June;107(3):173-81

language: English

The contribution of thyroid autoimmunity to miscarriage in euthyroid women

Chunmei LIN, Yang XIANG, Jing LI

Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang, China


The presences of antithyroid autoantibodies (ATA), such as thyroid peroxidase-specific antibody and/or thyroglobulin-specific antibody, are considered as the markers of thyroid autoimmunity, which have been found highly associated with pregnancy loss in euthyroid women. Miscarriage is a multifactorial problem that is not rare in women of reproductive age. Increased prevalence of ATA has been reported in women with a history of abortion. High risk of miscarriage has also been found in those with thyroid autoimmunity. In the present study, we used a myriad of correlative and latest papers till March 2016, including randomized clinical trials, case-control and cross sectional studies, to provide a comprehensive review of the literature to investigate the potential role of thyroid autoimmunity in pathogenesis of miscarriage.

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