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Minerva Medica 2015 June;106(3):169-75

language: English

An update on the use of melatonin as a stroke therapeutic

Gonzales-Portillo G. S., Lozano D., Aguirre D., Reyes S., Borlongan C. V., Tajiri N., Kaneko Y.

Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA


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Delivery of melatonin and targeting melatonin receptors pose as neuroprotective strategies for stroke therapy. The potential of melatonin-based therapeutics for clinical application in stroke patients requires translational research to guide the conduct of clinical trials. We review recent preclinical and clinical data that support the use of melatonin for stroke.

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ntajiri@health.edu